By: Manoj Prasad
New research found links between high blood levels of niacin byproduct 4PY and increased cardiovascular inflammation and event
4PY accumulates when body metabolizes more niacin than required through fortified foods, supplement
Study analyzed 1,100 people - higher 4PY associated with greater heart disease risk
Provides evidence excess niacin may fuel vessel inflammation, plague buildup over time
Many grains/cereals fortified with niacin, easily consume excess without realizing
Recommend evaluating whole diet first before taking niacin supplement
More research needed, but findings may inform future niacin intake recommendation
Could lead to new anti-inflammatory therapies to lower CVD risk
For now, use caution with routine niacin supplement intake unless deficiency