Too Much of a Good Thing? High Vitamin B3 Levels Tied to Heart Risk

By: Manoj Prasad

New research found links between high blood levels of niacin byproduct 4PY and increased cardiovascular inflammation and event

4PY accumulates when body metabolizes more niacin than required through fortified foods, supplement

Study analyzed 1,100 people - higher 4PY associated with greater heart disease risk

Provides evidence excess niacin may fuel vessel inflammation, plague buildup over time

Many grains/cereals fortified with niacin, easily consume excess without realizing

Recommend evaluating whole diet first before taking niacin supplement

More research needed, but findings may inform future niacin intake recommendation

Could lead to new anti-inflammatory therapies to lower CVD risk

For now, use caution with routine niacin supplement intake unless deficiency